Study on the mechanical response of anticlastic cold bending insulating glass and its coupling effect with uniform load.

Cold bending is a characteristic of significance for the beautiful curved glass curtain walls, because it affects them in terms of energy-efficiency and cost-efficiency. The increasing engineering projects call for more special studies on the mechanical properties of cold-bent glass panels, especially when the walls are built by insulating glass that is currently widely used while its relevant research is very scarce. This paper is devoted to studying the mechanical properties of anticlastic cold-bent insulating glass while taking different factors into consideration, including glass thickness, cold-bent torsion rate and cavity thickness. 9 pieces of insulating glass were manufactured for anticlastic cold-bending test and their coupled effect with identical load is also studied, and numerical finite element analysis sessions were carried out to simulate the experimental results for each one of them. Further, we analyzed the stress distribution performance of the sample pieces under cold bending and a uniform load, followed by discussions about stress transfer controls in glass plates. The results showed that the cold-bent control stress is on the surface with direct loads from cold bending and close to the cold-bent corner on the short edge, and it is transferred from the parts around the corner to the center when the uniform load plays a leading role in generating stress. This transfer could occur under a relatively small load with a small cold-bent torsion rate. A higher cold-bent torsion rate in cold bending contributed mostly to greater center stress in the glass, and as the glass thickness grows, stress and deflection at the plate center would significantly drop. However, the effect of cavity thickness on the anticlastic mechanical response of insulating glass was found to be trivial.

Selective antibacterial activity of patchouli alcohol against Helicobacter pylori based on inhibition of urease.

The aim of this study is to evaluate the antibacterial activity and urease inhibitory effects of patchouli alcohol (PA), the bioactive ingredient isolated from Pogostemonis Herba, which has been widely used for the treatment of gastrointestinal disorders. The activities of PA against selected bacteria and fungi were determined by agar dilution method. It was demonstrated that PA exhibited selective antibacterial activity against Helicobacter pylori, without influencing the major normal gastrointestinal bacteria. Noticeably, the antibacterial activity of PA was superior to that of amoxicillin, with minimal inhibition concentration value of 78 µg/mL. On the other hand, PA inhibited ureases from H.pylori and jack bean in concentration-dependent fashion with IC50 values of 2.67 ± 0.79 mM and 2.99 ± 0.41 mM, respectively. Lineweaver-Burk plots indicated that the type of inhibition was non-competitive against H.pylori urease whereas uncompetitive against jack bean urease. Reactivation of PA-inactivated urease assay showed DL-dithiothreitol, the thiol reagent, synergistically inactivated urease with PA instead of enzymatic activity recovery. In conclusion, the selective H.pylori antibacterial activity along with urease inhibitory potential of PA could make it a possible drug candidate for the treatment of H.pylori infection.